Zinc/Copper imbalance

An imbalance in serum/plasma levels of zinc and copper has been associated with anxiety and other psychiatric disorders ever since Carl C. Pfeiffer's 1970 studies. With a recent study, A.J. Russo, Research Director of the Pfeiffer Treatment Center, Illinois, has confirmed the importance of the zinc/copper relationship in the treatment of anxiety.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738454